Figure_6.tif (373.95 kB)
LyGDI is a negative regulator of FcγR-mediated phagocytosis.
figure
posted on 2013-02-20, 17:38 authored by Payal Mehta, Anne-Sophie Wavreille, Steven E. Justiniano, Rachel L. Marsh, Jianhua Yu, Richard W. Burry, David Jarjoura, Timothy Eubank, Michael A. Caligiuri, Jonathan P. Butchar, Susheela TridandapaniControl and LyGDI siRNA-transfected THP-1 (A) or PBM (B) were incubated with fluoresceinated, IgG-coated sheep red blood cells (SRBC) at 37°C for 40 minutes. Phagocytosis was measured by counting the total number of SRBC ingested by 100 transfectants and is plotted as the phagocytic index. Three independent experiments were performed and scored in a blinded fashion. Data were analyzed by Student's t-test (* denotes p<0.05).
