Lungs of mice with chronic granulomatous disease (CGD) or hydrocortisone-treated BALB/c mice inoculated with Aspergillus fumigatus isogenic strains, AFB62 and AFB62F9.

(A-D) Lungs of CGD mice. (E-H) Lungs of hydrocortisone-treated BALB/c mice. (A, B, E and F) Lungs of mice inoculated with AFB62. (C, D, G and H) Lungs of mice inoculated with AFB62F9. Numerous granulomas (A and C) with extensive hyphal growth (B and D) are seen in the lungs of CGD mice at nine days post fungal inoculation. Extensive hyphal growth (arrows in F and H) is seen in the bronchial tree in lungs of hydrocortisone-treated BALB/c mice at seven days post fungal inoculation. CGD and hydrocortisone-treated BALB/c mice were inoculated with 30 μl of 3.33x10⁵ and 3.33x10⁷ conidia/ml, respectively, via pharyngeal aspiration. Sections were stained with hematoxylin and eosin (A, C, E and G) and Gomori methenamine silver (B, D, F and H).