Links between <i>C/ebpα</i> and <i>Clock</i> gene expressions.

<p>An interactive feedback loop between <i>C/ebpα</i> and the core clock genes feedback loop is indicated. The core clock genes feedback loop is enclosed in an oval. Transcriptional activators CLOCK and BMAL1 drive <i>Per2</i> and <i>C/ebpα</i> gene expression. Per and CRY proteins inhibit CLOCK/BMAL1 activity. Thick line denotes regulation based on present findings. Dotted arrow comes from other papers <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058221#pone.0058221-Gery2" target="_blank">[20]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058221#pone.0058221-Oishi3" target="_blank">[21]</a>.</p>