Laser-induced choroidal neovascularization (CNV) is enhanced in rats fed with a 60%-rich fructose diet.

A. Representative images of choroidal indocyanine green angiography taken after 1 and 3 weeks post laser-induced CNV in rats fed with either the standard or 60%-rich fructose diet. Images were taken at 20° by confocal scanning laser ophthalmoscopy at 795 nm. The black holes in the eye fundi at 1 week post laser-induced CNV correspond to the breaks created by the laser spots (532 nm, 300 mW, 50 ms, 75 µm) in the retinal pigment epithelium and Bruch's membrane. CNV correspond to the filling of the new vessels by indocyanine green. B. Semi-quantification of CNV (ratio between the area of indocyanine green fluorescence and optic disc area) at 2 and 3 weeks after laser-induced CNV in the rat fed during 1, 3, and 6 months with either the standard (S) or 60%-rich fructose (F) diet. * and ** statistically different at p≤0.05 and 0.01, respectively (Kruskal-Wallis test). Values are given as individual data and means ± SD (n = 8 rats per group).