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Lack of dermal residing MF does not alter filarial-specific antibody profiles.
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posted on 2014-02-20, 02:44 authored by Kathrin Arndts, Sabine Specht, Alexander Y. Debrah, Francesca Tamarozzi, Ute Klarmann Schulz, Sabine Mand, Linda Batsa, Alexander Kwarteng, Mark Taylor, Ohene Adjei, Coralie Martin, Laura E. Layland, Achim HoeraufPlasma samples from all participants (NEN, MF+ and a-MF) were investigated for the presence of filarial-specific Igs by ELISA. Plates were coated overnight with 5 µg/ml O. volvulus worm extract. Thereafter, levels of IgE (A) and IgG4 (B) were detected in all individual samples diluted 1∶20 and 1∶500 respectively. Data are depicted as absolute values expressed in arbitrary units [AU]. Graphs show box whiskers with median, interquartile ranges and outliers. Statistical significances between the indicated groups were obtained after Kruskal-Wallis and Mann-Whitney tests. Data in (C) show the correlation of dermal MF with the amount of filarial-specific IgG4; determined using the Spearman correlation test.
