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LTP levels of mtALR, mt129S1 and control strains at the age of 6 months.

figure

posted on 2015-04-08, 04:08 authored by Johannes Mayer, Gesine Reichart, Tursonjan Tokay, Falko Lange, Simone Baltrusch, Christian Junghanss, Olaf Wolkenhauer, Robert Jaster, Manfred Kunz, Markus Tiedge, Saleh Ibrahim, Georg Fuellen, Rüdiger Köhling

(A) Time course of field excitatory postsynaptic potentials (fEPSP) measured in Schaffer collateral-CA1 synapses from mtALR (n = 6 slices / 4 animals), mt129S1 (n = 9 slices / 5 animals), and control strains BL6 (n = 5 slices / 4 animals) and mtAKR (n = 18 slices / 13 animals). Each circle represents the percentage of fEPSP slope relative to mean baseline value. Following a 10 min baseline recording, three times of theta-burst stimulation protocol (TBS) was delivered at time point 0 indicated by black arrow. Superimposed traces above show representative fEPSPs from each strain before and 55 min after TBS. (B) Bar graphs show mean values of LTP, calculated between minute 55 and minute 60 after TBS stimulation relative to baseline. Both, mtALR and mt129S1 did not show any significant differences in LTP levels compared to control strains. Diamonds (◊) show statistical significance of LTP level relative to baseline (p < 0.05). All mean values are presented with error bars (± SEM).