Knockout of DR5 by siRNA attenuated the effect of co-treatment of casticin and TRAIL on apoptotic cell death of BGC-823 cells.

<p>Action of siRNA for DR5, on the effects of casticin-induced DR5 expression levels (A) using western blot analysis and TRAIL-mediated apoptosis (B). <sup>*</sup><i>P<0.05</i> vs. treatment with DMSO; <sup>#</sup><i>P<0.05</i> vs. treatment with 1 µmol/l casticin plus 50 ng/ml TRAIL in control and scRNA transfected cells.</p>