Knockout of DR5 by siRNA attenuated the effect of co-treatment of casticin and TRAIL on apoptotic cell death of BGC-823 cells.

Action of siRNA for DR5, on the effects of casticin-induced DR5 expression levels (A) using western blot analysis and TRAIL-mediated apoptosis (B). ^*P<0.05 vs. treatment with DMSO; ^#P<0.05 vs. treatment with 1 µmol/l casticin plus 50 ng/ml TRAIL in control and scRNA transfected cells.