Kaplan-Meier plots of recurrence free survival in breast cancer patients from the I SPY-1 cohort predicted by the Tc/ClassII immune signature score, alone and in conjunction with PCNA<sup>+</sup> TAM counts.

<p>(A) Kaplan-Meier curves for recurrence free survival (RFS) were stratified by the median Tc/ClassII signature score into low (n=38) or high (n=42) subsets. (B) Kaplan-Meier curves for RFS comparing patients with high PCNA<sup>+</sup> TAMs and a low Tc/ClassII score (n=11) to all other patients (n=69). (C) Kaplan-Meier curves for RFS in hormone receptor negative cases only; high PCNA<sup>+</sup> TAMs and a low Tc/ClassII score (n=7) to all other HR negative cases (n=26). Differences between groups were assessed using the log rank test, with p values indicated in each plot.</p>