Interactome networks.

Interactome networks for DE (A, B) and CO (C, D) hubs/high-hubs (depicted in red) and VIPs (depicted in blue) using MINT, HPRD and IntAct databases for FS (A, C) and NFS (B, D) groups. Node shapes and colors represent biological processes, as follows: diamond for actin/cytoskeleton; hexagon for signaling (blue or pink borders stands for neurotransmission or inflammation); octagon for calcium ion binding/transport/homeostasis; octagon with blue or pink border stand for cation channel or cation transport respectively; parallelogram for cell-cell interaction/adhesion; rectangle for cell processes (blue or green borders stand for apoptosis or proliferation); bordered triangles stand for synaptic transmission/SNARE complex (light blue), voltage-gated ion channel activity (pink), GABAergic synaptic transmission (red), synaptic transmission (green) and neuronal differentiation/motility (purple); vee for cholesterol homeostasis; ellipse for other processes. Nodes in red represent high-hubs or hubs in CO or DE transcriptional networks, respectively; Nodes in blue represent VIPs in CO and DE transcriptional networks; Node size is related to node degree (number of links). Links in red represent the first and second hub connections, centered in DE or CO VIPs.