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In the absence of Tregs, mice show exacerbated inflammatory responses.

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posted on 2015-10-29, 03:23 authored by Silvia B. Bazan, Tania A. Costa, Eliseu Frank de Araújo, Claudia Feriotti, Flávio V. Loures, Fernando D. Pretel, Vera L. G. Calich

(A) Photomicrographs of lungs, livers and spleens from Rag1-/- mice infected with Pb18 after adoptive cell transfer of Treg, CD4+Foxp3- T cells and Treg + CD4+Foxp3- T cells. Organ sections were stained with H&E and Grocott and examined under a light microscope with a magnification of 100×. Morphometric analysis of lesions in lungs, livers and spleens from Rag1-/- mice after 6 weeks of infection with Pb18. (B) Areas of lesions were quantified from photomicrographs of organ sections. Data represent the mean ± SD from three experiments (n ≥ 5; *p < 0.05; ** p < 0.005; ***p < 0.001; ND = not detectable).

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