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Impact of cold-stress following lethal irradiation.

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posted on 2015-03-20, 04:11 authored by Benjamin J. Povinelli, Kathleen M. Kokolus, Jason W.-L. Eng, Christopher W. Dougher, Leslie Curtin, Maegan L. Capitano, Christi T. Sailsbury-Ruf, Elizabeth A. Repasky, Michael J. Nemeth

After acclimation, C57BL/6 mice were irradiated with 900 cGy and assessed 2, 6, and 9 days following radiation treatment. A: Kaplan-Meier curves indicating survival of mice housed at ST (solid line) versus TT (dotted line) following irradiation (n = 10). P-value was calculated using the Mantel-Cox test. B: Average body weight of mice housed at ST (solid line) versus TT (dotted line) following irradiation (n = 10). C: Average peripheral white blood cell (WBC) count (right) in acclimated mice mice. D: Average peripheral white blood cell count (WBC) of mice housed at ST (solid line, circles) versus TT (dotted line, triangles) following irradiation (n = 10). E-H: Average levels of hemoglobin (E), red blood cells (RBC, F), platelets (F), neutrophils (G), and lymphocytes (H) in mice housed at ST (solid line) versus TT (dotted line) following irradiation (n = 10 for all panels). I: Average percentage of neutrophils (left) and lymphocytes (right) in white blood cells (WBC) in ST (black bar) versus TT mice (gray bar, n = 10). For all panels, data are presented as mean ± SEM and p-values calculated using Student’s t test.