Illustrates the comprehensive analyses of central proteins as potential drug targets.
The various filters include comparison with validated drug targets, sequence and structural level comparison with Human proteome, gut and oral flora (a) The list of 73 central ORFs wherein Rv Ids in bold represent IPW central ORFs, Rv IDs in regular font represents IPWSI central ORFs and the italicized-bold represent common Rv Ids to both IPW and IPWSI. (b & b’) Five of the 17 IPW and six of 64 central ORFs with experimental validation as drug targets. (c) Sequence homology comparison with human proteome and human microbiome results in 62 ORFs with no significant similarity (d) Octamer analyses against human proteome and human microbiome results in one ORF with no hits (e) Comparative binding site analysis with human proteome results in 26 ORFs with no significant similarity (lists b, b’, c, d and e available in Table S2).