Identified blocks of conserved synteny around paralemmin genes in human, chicken, zebrafish and stickleback.

Gene families that were selected had members located within ±5 Mb of at least three different paralemmin genes in the human genome. Genes in boxes with dashed frame were not included in the phylogenetic analyses (see Results). Gene family abbreviations: ATP-binding cassette sub-family A (ABCA), calponin (CNN), paralemmin downstream genes (PDG), plasticity related genes (PRG), polypyrimidine tract-binding protein (PTBP), sphingosine-1–phosphate receptors (S1PR). These gene families have additional members on separate chromosomes, not part of these identified blocks of conserved synteny (Table S1, Figure 5, Figures S1, S2, S3, S4, and S5); for the S1PR family these are S1PR1, S1PR3 and S1PR4 on zebrafish chromosome 22 and S1PR1 on stickleback group VIII; for the CNN family, CNN1A is located on chromosome 1 in zebrafish; for the ABCA family, ABCA1 in zebrafish is located on chromosome 1 and ABCA4A in stickleback is located on group XXI.