Figure 2.tif (1.35 MB)
ISO-dependent leak is attenuated by NOS inhibitor, L-NAME.
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posted on 2014-02-03, 19:38 authored by Jerry Curran, Lifei Tang, Steve R. Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M. Bers, Peter J. Mohler, Mark T. Ziolo, Thomas R. ShannonA) The leak-dependent shift of Ca2+ from the cytosol to the SR. Each point represents a loading protocol (from low to high [Ca]SRT; resting, 1 field stimulation, 0.25 Hz, 0.5 Hz and 1 Hz stimulation, respectively). B) The SR Ca2+ leak (right) in [Ca]SRT matched data (left, n = 10–14). C) The [Ca]SRT (right) needed to induce the same SR Ca2+ leak (left) in leak matched data (left, n = 11–17). *Statistically different from control, #different from ISO (t-test, p<0.05).
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diastolic sarcoplasmic reticulum releasenitric oxide synthase 1 activationnitric oxide synthase 1nitric oxide synthase 3.isoproterenol stimulationCaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Releasereactive oxygen speciesadrenergic cascadenitric oxide synthasemyocytenitric oxide productiondata links AktSRAdrenergic Stimulation Spontaneous calcium wavesARnitric oxidemediates CaMKII activityleak
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