Figure_8.tif (366.05 kB)
Hypothetic mechanisms of anti-PCa effects of Triptolide.
figure
posted on 2012-05-30, 00:32 authored by Weiwei Huang, Tiantian He, Chengsen Chai, Yuan Yang, Yahong Zheng, Pei Zhou, Xiaoxia Qiao, Bin Zhang, Zengzhen Liu, Junru Wang, Changhong Shi, Liping Lei, Kun Gao, Hewei Li, Sue Zhong, Libo Yao, Meng-Er Huang, Ming LeiTriptolide suppresses SENP1, AR and c-Jun expression, induces restoration of SUMOylation/deSUMOyaltion balance, inhibitions of the AR and c-Jun mediated transcription, which may all contribute to the anti-PCa effect of Triptolide. Other genes or proteins may involve in mechanism of Triptolide effect (see Discussion for detail).
