Fig_6.tif (1.23 MB)
Histological analysis of the liver of MC4R-KO mice treated with EPA for 4 weeks after the development of NASH.
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posted on 2015-03-27, 04:32 authored by Kuniha Konuma, Michiko Itoh, Takayoshi Suganami, Sayaka Kanai, Nobutaka Nakagawa, Takeru Sakai, Hiroyuki Kawano, Mitsuko Hara, Soichi Kojima, Yuichi Izumi, Yoshihiro Ogawa(A) Experimental protocol of therapeutic EPA treatment. Fibrillar collagen deposition evaluated by Masson-trichrome staining (B) and fibrosis scores (C). (D) Quantification of Sirius red-positive area. Scores of steatosis, lobular inflammation, ballooning degeneration (E) and NAS (F). Scale bars, 50 μm. * P < 0.05; ** P < 0.01; n.s., not significant. MC4R-control, n = 7; MC4R-EPA Pre, n = 10.
