Het GIP Tg mice exhibit reduced weight gain and insulin resistance on HF diet.

<p>Het GIP Tg (Tg/+) and non-transgenic WT littermates (+/+, 5 weeks old) were placed on either a low fat (LF) or high fat (HF) diet, and 25 mM ZnSO<sub>4</sub> was added to the drinking water of both Het GIP Tg and WT mice (<i>n</i> = 6/group). <b>A.</b> Body weight gain in Het GIP Tg and WT mice placed on LF or HF diet. <b>B.</b> Percentage fat gain in WT and Het GIP Tg mice. <b>C.</b> Percentage fat of WT and Het GIP Tg mice on 14 weeks old. <b>D and F.</b> Glucose levels during an insulin tolerance test in LF (<b>D</b>)- and HF (<b>F</b>) diet-fed Het GIP Tg and WT littermates. After 8 weeks of feeding, WT and Het GIP Tg mice (13 weeks old, <i>n</i> = 6/group) were fasted for 4 hours and subsequently injected with 0.75 U/kg insulin. Blood glucose levels measured at 0, 15, 30, 60 and 120 min following insulin administration. <b>E and G.</b> Quantification of AUC for the total glycemic excursions in <b>D</b> and <b>F.</b> All data represent the mean ± S.E.M. and significance was tested using ANOVA with a Newman-Keuls post hoc test or Student’s <i>t</i> test, where ** represents p<0.05 <i>vs</i> indicated group or WT littermates.</p>