Haplotype analysis from all breeds identified two risk haplotypes in cases and nine non-risk haplotypes in controls.

The upper panel indicates the alternative alleles in different grey shades, and the defined ~167 kb risk haplotype (4,915,018–5,081,823 bp) with red boundaries. Proportion of risk/non-risk haplotypes indicates the relative proportions of corresponding haplotypes among risk haplotypes determined in cases or non-risk haplotypes determined in controls, respectively. Star indicates a rare haplotype represented by only one chromosome. The lower panel shows the genomic location of the SNPs defining the risk haplotype in relation to protein coding genes (for each gene all the transcripts isoforms are included), CpG islands and conservation scores (figure adapted from: http://genome.ucsc.edu)