H&E staining of pancreata from RARE-LacZ mice treated with caerulein (A), and subsequent recovery for 2 weeks (B), 4 weeks (C) and 6 weeks (D).

<p>RA signalling activity in pancreata from RARE-LacZ mice treated with caerulein (E), and subsequent recovery for 2 weeks (F), 4 weeks (G) and 6 weeks (H). Increased retinoid signaling activity was observed in a significant proportion of acinar cells immediately following cessation of caerulein treatment (E), with retinoid activity peaking at 2 weeks (F), diminishing at 4 weeks (G) and returning to near normal levels following 6 weeks of recovery (H).</p>