Figure_7.tif (3.26 MB)
Gene-gene interactions between RORA and NPSR1.
figure
posted on 2013-04-03, 08:28 authored by Nathalie Acevedo, Annika Sääf, Cilla Söderhäll, Erik Melén, Jami Mandelin, Christina Orsmark Pietras, Sini Ezer, Piia Karisola, Johanna Vendelin, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Harri Alenius, Erika von Mutius, Gert Doekes, Charlotte Braun-Fahrländer, Josef Riedler, Marianne van Hage, Mauro D’Amato, Annika Scheynius, Göran Pershagen, Juha Kere, Ville Pulkkinen(A) Heatmap of the p-values for interaction between 35 RORA SNPs (y-axis) and 8 NPSR1 SNPs (x-axis). A schema of the NPSR1 gene is presented at the bottom of the figure with the relative positions of the SNPs. The alleles comprising the CAC haplotype are marked in red. (B) Effects of one (TC) or two copies (CC) of the RORA SNP rs7164773 on asthma risk according to the genotypes on the NPSR1 SNP rs6972158 (Gln344Arg). Bars represent 95% confidence intervals. (C) Effects of RORA rs8024629 and RORA rs9302215 on asthma risk according to the functional NPSR1 haplotype CAC (rs2530547C/rs324981A/rs727162C). All the results for gene-gene interactions analysis are presented after adjustment by age and country of origin.
