Expression of ErbB3, ErbB2 and c-MET in human colorectal cancer.

(A, B, C) Expression of ErbB3, ErbB2 and c-MET in human colorectal cancer. Specimens of 105 paraffin-embedded colorectal cancer tissues were analyzed by IHC for ErbB3, ErbB2 and c-MET, and representative figures show strong and weak/negative staining for each marker with respective normal control samples. Average integrated optical density (IOD) was obtained by analyzing five fields for each slide, evaluated by Image-Pro Plus software (version 5.0) for IHC staining of ErbB3, ErbB2 and c-MET. The data are presented as mean ± SD, and *P<0.05, **P<0.01 by Mann-Whitney U test.