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Expression of CXCR7, and its ligand CXCL12 in a NB TMA.

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posted on 2012-08-20, 00:02 authored by Julie Liberman, Hervé Sartelet, Marjorie Flahaut, Annick Mühlethaler-Mottet, Aurélie Coulon, Carine Nyalendo, Gilles Vassal, Jean-Marc Joseph, Nicole Gross

(A) Semi-quantitative assessment of CXCR7 and CXCL12 expression levels in neural, endothelial and stromal cell compartments of NB primary tumors. Median score represents the average of the immunostaining score (0–4). Percentage (%) indicates percentage of CXCR7-or CXCL12-positive tumor tissues. (B) Immunohistochemical analysis of CXCR7 in undifferentiated tumor (UnNB), ganglioneuroblastoma (GGNB), ganglioneuroma (GGN) and control normal sympathetic ganglion (SG) tissues. Black arrow: ganglion cell. (C) CXCR7 expression levels (median score) in UnNBs, in differentiated tumor tissues, (D) and in tumors of patient according to the age of patient at diagnosis. (E) Immunohistochemical analysis of CXCL12 in UnNBs, GGNBs, GGNs and SG tissues. Red arrow: endothelial cell. (F) CXCL12 expression levels (median score) in the endothelial compartment of tumors according to the age of patient at diagnosis, (G) and in the stroma of UnNBs, GGNBs and GGNs. Student’s t-test: *p<0.05, **p<0.01.