Figure_8.tif (1.6 MB)
Example of 9 clusters of genetic risk profiles in centenarians of the discovery set and 3 similar clusters in replication sets 1 and 2.
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posted on 2012-01-18, 00:26 authored by Paola Sebastiani, Nadia Solovieff, Andrew T. DeWan, Kyle M. Walsh, Annibale Puca, Stephen W. Hartley, Efthymia Melista, Stacy Andersen, Daniel A. Dworkis, Jemma B. Wilk, Richard H. Myers, Martin H. Steinberg, Monty Montano, Clinton T. Baldwin, Josephine Hoh, Thomas T. PerlsIn each plot, the x-axis reports the number of SNPs in each genetic risk model (1,…,281), and the y-axis reports the posterior probability of exceptional longevity predicted by each model. The boxplots (one for each SNP set on the x axis) display the genetic risk profiles of the centenarians grouped in the same cluster. Numbers N in parentheses are the cluster sizes, and the average posterior probability of exceptional longevity. Color coding represents the strength of the genetic risk to predict EL (Blue: P(EL|∑281)>0.95; Red: 0.5281)<0.95; Orange: 0.20281)<0.5; Green: P(EL|∑281)<0.2). The full set of 26 clusters is in Figure S11 and includes more than 90% of centenarians in the discovery set.
