Evoked firing properties of APP/PS1 PCs.

(A) Wild-type (blue) and APP/PS1 (red) PC evoked action potential firing. In the wild-type trace, the first three interspike intervals (ISI) are shown. (B) Mean latency of the first spike for PCs from wild-type (n = 14) and APP/PS1 (n = 20). The difference is not significant (P>0.05). (C) Plot of the first three ISIs of wild-type (n = 14) and APP/PS1 (n = 20) mice PCs. The second and third ISIs are significantly prolonged in APP/PS1 mice (*p<0.05, t test).