Electron micrographs of rod cells from 1-month old mice with the P23H transgene in combination with different numbers of wild type rhodopsin genes.

<p>Genotypes are abbreviated at the top: 1 Rho+P23H is mRho<sup>+/−</sup>P23H<sup>+/0</sup>, 2 Rho+P23H is mRho<sup>+/+</sup>P23H<sup>+/0</sup>, and 3 Rho+P23H is mRho<sup>+/+</sup>NHRE<sup>+/0</sup>P23H<sup>+/0</sup>. The top row of images is at 700X magnification, the middle row is at 4400X, and the bottom row is at 12000X, with scale bars indicating 11 µm, 1.7 µm, and 0.6 µm, respectively.</p>