Effects of visfatin on locomotor activity and body temperature.

Locomotor activity and body temperature were measured for 24 h after ICV administration of visfatin. (A) ICV injection of visfatin resulted in decreased locomotor activity during the dark period, but there was no change in activity during the light period. (B) Body temperature began to increase 2 h after ICV injection of visfatin and remained high until about 20 h after injection. Mean temperature after the injection time (at 0 h) was significantly different between groups. Data are represented as mean ± SEM (n = 10). ***P<0.001 vs. control rats injected with 0.9% saline solution.