Effects of replenishment of IL-13 in DSS-induced colitis.

IL-13−/− mice were treated with rmIL-13 (2 µg/day) injections or vehicle. rmIL-13 treatment started 3 days prior to 5 days of 5% DSS treatment. All groups received 5% DSS in the drinking water to induce colitis. (A) DAI. (B) Macroscopic damage score (C) Histologic scores and (D) MPO activity. (i) and (ii) Representative light micrograph of an H&E-stained colonic section. DAI data represented as mean ± SEM from 4 mice; *represents statistical significance where p<0.05; a, b and c represents statistically significant difference in disease activity scores on days indicated, where p<0.05.