Effects of curcumin on CNV formation.

(A) Representative micrographs of CNV lesions in the RPE–choroid flat mounts from vehicle-treated mice and curcumin-treated mice on day 7 and day 14 after laser photocoagulation. CNV is indicated by green fluorescence and FITC-dextran angiography. Scale bar = 100 µm. (B) Quantitative analysis of CNV size in RPE–choroid flat mounts. Day 7: Vehicle, n = 42 spots; 10 mg/kg curcumine, n = 45 spots; 30 mg/kg curcumine, n = 42 spots; 90 mg/kg curcumine, n = 39 spots. Day 14: Vehicle, n = 66 spots; 10 mg/kg curcumine, n = 54 spots; 30 mg/kg curcumine, n = 60 spots; 90 mg/kg curcumine, n = 63 spots. *P<0.05; **P>0.05.