Figure_8.tif (1023.99 kB)
Effects of adefovir and PMEO-DAPym on mortality in mice inoculated with HSV-1 or HSV-2.
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posted on 2013-07-25, 02:07 authored by Jan Balzarini, Graciela Andrei, Emanuela Balestra, Dana Huskens, Christophe Vanpouille, Andrea Introini, Sonia Zicari, Sandra Liekens, Robert Snoeck, Antonín Holý, Carlo-Federico Perno, Leonid Margolis, Dominique ScholsGroups of five nu/nu mice were inoculated with HSV-1 (panel A) or HSV-2 (panel B) on the lumbosacral area. Each cohort was then subjected to topical treatment twice daily for 5 consecutive days, starting on the day of viral infection. The placebo groups received a similar treatment with the test formulation without drug. Mortality was recorded over a period of 30 days. Animals were euthanized when more than 30% loss in body weight or development of paralysis occurred. We estimated survival rates according to the Kaplan-Meier method and compared them using the log-rank test (Mantel-Cox using GraphPad Prism). Several curves proved statistically significant (p<0.01) in comparison of each treatment with placebo.