Fig_7.tif (3.56 MB)
Effects of Pitavastatin-NP on inflammation and apoptosis in IR myocardium 24 hours after reperfusion.
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posted on 2015-07-13, 03:27 authored by Kazuhiro Nagaoka, Tetsuya Matoba, Yajing Mao, Yasuhiro Nakano, Gentaro Ikeda, Shizuka Egusa, Masaki Tokutome, Ryoji Nagahama, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira(A), Representative photomicrographs of cross-sections from IR myocardium stained with NF-B (p65 subunit), MCP-1, ED-1 and TUNEL. Scale bar: 20 μm. (B), Quantification of the number of NF-B (p65 subunit) positive cells, the MCP-1-positive area, ED-1-positive leukocytes (monocytes) in IR myocardium and the number of TUNEL-positive cells in infarct border myocardium 24 hours after reperfusion. Data are mean±SEM (n = 5–8 per group). Data are compared using one-way ANOVA followed by Dunnett’s multiple comparison tests.
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IR myocardiumgskPI 3K inhibitor wortmanninfitcPitavastatin Induces CardioprotectionCD 11b leukocytesamiinterventional reperfusion therapyAcute Myocardial InfarctionRat Model AimThereMI sizePI 3K pathwayNew Therapeutic Modalitypitavastatinplgamitochondrial permeability transition pore inhibitor cyclosporinecardioprotective modalityrat IR model
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