Figure_5.tif (503.79 kB)
Effects of GDC0941 and AZD6244 on PI3K/AKT and MEK/ERK pathways of MIA PaCa-2 and PANC-1 cell lines.
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posted on 2013-10-09, 03:20 authored by Hua Zhong, Cesar Sanchez, Dirk Spitrzer, Stacy Plambeck-Suess, Jesse Gibbs, Williams G. Hawkins, David Denardo, Feng Gao, Robert A. Pufahl, Albert C. Lockhart, Mai Xu, David Linehan, Jason Weber, Andrea Wang-GillamBoth MIA PaCa-2 and PANC-1 cells were treated with 400 nm GDC0941, 200 nM AZD6244 or a combination at these doses for 24 hours. Cell proteins were then harvested to detect p-AKT(S473)/AKT, p-ERK(T202/Y204)/ERK, p-S6(S240/244)/S6 and p-4E-BP1(S65)/4E-BP-1.
