Figure_6.tif (203.21 kB)
Effects of GDC0941 and AZD6244 on BxPC-3 xenograft model.
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posted on 2013-10-09, 03:20 authored by Hua Zhong, Cesar Sanchez, Dirk Spitrzer, Stacy Plambeck-Suess, Jesse Gibbs, Williams G. Hawkins, David Denardo, Feng Gao, Robert A. Pufahl, Albert C. Lockhart, Mai Xu, David Linehan, Jason Weber, Andrea Wang-GillamA: 1×106 BxPC-3 pancreatic cancer cells were injected s.c. into the right flank of female nude mice. Mice received vehicle (0.5% methylcellulose /0.2% Tween-20), 50 mg/kg GDC0941 QD, 25 mg/kg AZD6244 BID, or 50 mg/kg GDC0941 QD plus 25 mg/kg AZD6244 BID orally for 18 days. Data are presented as mean ± SE. *p values were determined by unpaired t-test. B: Kaplan-Meier survival curves of xenografts receiving vehicle, GDC0941 alone, AZD6244 alone and GDC0941-AZD6244 in combination.
