Effects of 4-week RMF exposure on trabecular bone microarchitecture in the distal femora and cortical bone thickness in the mid-diaphyseal femora.

(A) The selected trabecular volume of interest (VOI) with yellow color in 2.0 mm height, which is represented with yellow color and only contains the secondary spongiosa. (B) 3-D µCT images of trabecular bone microarchitecture determined by the VOI. (C) 2-D µCT images of trabecular bone microarchitecture from the axial, coronal and sagittal plane observation in the distal femora, and cortical bone images in the femoral mid-diaphysis. The rat femur in the HU group exhibited significant decrease in the trabecular number, trabecular area and cortical thickness as compared with that in the Control group, whereas RMF exposure did not exhibit remarkable effects on trabecular bone microarchitecture and cortical bone thickness in HU rats.