Figure_4.tif (4.56 MB)
Effect of graded number of MSCs on renal function and morphology after I/R injury.
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posted on 2014-03-17, 02:45 authored by Jieru Cai, Xiaofang Yu, Rende Xu, Yi Fang, Xiaoqin Qian, Shaopeng Liu, jie Teng, Xiaoqiang Ding(A) In RA group with PBS only, no further increasing Scr level was detected (5.01±0.87 mg/dl) compared with control group (5.22±0.43 mg/dl). (B) In CA group, the Scr level decreased with increased amounts of injected MSCs. However, in RA group, there was a U-type change and the lowest Scr level was obtained with 1×105 MSCs (3.71±0.96 mg/dl), which was significantly lower than that in all groups, including CA group and RA group (P<0.05). (C–D) Histological examination (HE staining, magnification 200×) showed that the most significant morphological improvement was found in RA group (1×105), which was consistent with functional studies. *P<0.05, vs CA group (1×106).
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cell biologyCellular typesAnimal cellsstem cellsmesenchymal stem cellsMolecular cell biologydevelopmental biologyCritical care and emergency medicinehematologyNephrologyRenal failureAcute renal failureSurgical and invasive medical proceduresBlood and lymphatic system proceduresStem cell transplantationtransplantationgradedmscsrenalmorphology
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