Effect of endoglin haploinsufficiency on extracellular matrix formation.

<p>(<b>A</b>) Synthesis of collagen Iα and fibronectin by <i>Eng<sup>+/+</sup></i> and <i>Eng<sup>+/−</sup></i> MDF were analyzed by RT-PCR. GAPDH was used as housekeeping (<b>B</b>) Synthesis of collagen Iα and fibronectin were also evaluated by western blot in total protein extracts from <i>Eng<sup>+/+</sup></i> and <i>Eng<sup>+/−</sup></i> MDF using Tubulin as loading control. A representative blot from three independent experiments is shown.</p>