Effect of crizotinib and alectinib on stimulus preference of retinal ganglion cells.

<p>(A and B) Post-stimulus time histogram before (pre), during (crizotinib), and after (wash) the application of 1.0μM of crizotinib in an OFF-cell (A) and in an ON-OFF cell (B). The bin size for the histogram was 50 ms. (C and D) Cumulative distributions of the differences in <i>SPI</i> for crizotinib and alectinib. The difference in <i>SPI</i> was calculated from the <i>SPI</i> values evaluated before and during drug application. The cells were divided into “Decrease” type (C) and “Increase” type (D) according to the change in the <i>SPI</i>. The difference in (D) was an absolute value. (E and F) STA before (pre), during (crizotinib), and after (wash) the application of crizotinib in the cells shown in Figs 2A (E) and B (F). The amplitude “A” was defined as the difference in light intensity between the maximum and the minimum (double-headed arrow). (G and H) Plot of the amplitude “A” before (pre) and during drug application (drug) for the cells shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135521#pone.0135521.t004" target="_blank">Table 4</a>. The cells were divided into “Decrease” type (G) and “Increase” type (H). **<i>P</i> < 0.01; *** <i>P</i> < 0.001; paired <i>t</i>-test.</p>