Effect of antimalarial treatment on the number of glomerular cells.

Animals were euthanized on day 5 or day 21 p.i., perfused, and the kidneys were collected for histologic analysis. The number of glomerular cells in the renal cortex was visualized using periodic acid−Schiff. Representative photomicrography of noninfected mice (control5d) (A), 5 days p.i. (infected5d) (B), noninfected mice that received treatment with antimalarial drugs (control+treated21d) (C), and infected mice that received treatment with antimalarial drugs (infected+treated21d) (D) (n = 6 per group). Bar = 40 µm. The number of glomerular cells is quantified in (E). The results are expressed as means ± standard error. *Statistically significant compared with control5d or control+treated21d. #Statistically significant compared with control5d or infected5d (P<0.05).