Fig_5.tif (1.38 MB)
Effect of EPA on hepatic TGFβ activation in MC4R-KO mice.
figure
posted on 2015-03-27, 04:32 authored by Kuniha Konuma, Michiko Itoh, Takayoshi Suganami, Sayaka Kanai, Nobutaka Nakagawa, Takeru Sakai, Hiroyuki Kawano, Mitsuko Hara, Soichi Kojima, Yuichi Izumi, Yoshihiro Ogawa(A) Immmunostaining with anti-R58 LAP-DP antibody to determine TGFβ activation in the liver after 24 weeks of EPA treatment. (B) Quantification of the R58 LAP-DP-positive area. (C) Hepatic mRNA expression of urokinase-type plasminogen activator receptor (uPAR). (D) Active TGFβ protein levels in the liver. Scale bars, 50 μm. * P < 0.05; ** P < 0.01. WT-SD, n = 8; MC4R-control, n = 7; MC4R-EPA Pre, n = 10.
