Figure_5.tif (416.13 kB)
Dkk1 inhibits Wnt signaling in HB1.F3.
figure
posted on 2008-12-18, 01:05 authored by Sung-Min Ahn, Kyunghee Byun, Deokhoon Kim, Kiyoung Lee, Jong Shin Yoo, Seung U. Kim, Eek-hoon Jho, Richard J. Simpson, Bonghee LeeA. TOPflash/FOPflash reporter assay shows that Dkk1 represses Wnt signaling in HB1.F3 in a dosage-dependent manner. Data are means±S.D. of triplicate samples. B. Dkk1 represses the expression of c-myc, one of the target genes of Wnt pathway, in HB1.F3 in a dosage-dependent manner. C. Dkk1 treatment induces the expression of oligodendrocytes markers (Olig2 and CNPase) in HB1.F3.
