Distribution of serotypes 6A, 6B, and 6C among <i>Streptococcus pneumoniae</i> isolates recovered from invasive pneumococcal disease (meningitis and bacteremia, n = 12,345) according to age group, from 2002 to 2011.

<p>Introduction of PCV7 in France, March 2002, for children at high risk for IPD; Generalization of PCV7 for children <2 years in 2006; Introduction of PCV13 in France, June 2010.</p><p>*Significant trend over the 5 periods, calculation was performed by the extended Mantel-Haenszel Chi square test for linear trend.</p><p>°Serotype conventionally determined as 6A that could not be further tested for serotype 6C.</p><p>NA, Not applicable; NS, not significant.</p>