Sera from 8-, 12-, 16-, and 20-week-old SR-A−/− NOD, SR-A+/− NOD and NOD female littermates were collected and analyzed by our standard IAA assay. Levels of IAA were significantly lower than NOD mice in 16- and 20-week-old SR-A−/− NOD littermates (* p<0.05 by Mann–Whitney U test).