Depletion of Treg cells induces balanced Th1/Th2/Th17 immunity in both stages of infection.
2015-10-29T03:23:37Z (GMT) by
<p>(A) Quantification of activated/memory and naïve CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes in lungs from mice treated with anti-CD25 or control IgG and analyzed after 2 (left) and 10 (right) weeks of infection. (B) mRNA relative expression of Tbet, GATA3, RORγC, Foxp3, PD-L1, CCR5, CCR6 and Granzyme B in lung cells of mice treated with anti-CD25 or control IgG, after 2 (top) and 10 (bottom) weeks of infection. <b>(C)</b> Cytokine quantitation by ELISA in lung homogenates from mice treated with anti-CD25 or control IgG. Bars show mean ± SD from at least five mice per group and are representative of three independent experiments (*<i>p</i>< 0.05, **<i>p</i> < 0.005, ***<i>p</i> <0.001).</p>