Data statistics.

<p>Values in the parentheses are for the highest resolution shell.</p>a<p><i>R</i><sub>merge</sub> = Σ<sub>h</sub>Σ<sub>j</sub>|<<i>I</i>><sub>h</sub>−<i>I</i><sub>h,j</sub>|/Σ<sub>h</sub>Σ<sub>j</sub><i>I</i><sub>h,j</sub>, where <<i>I</i>><sub>h</sub> is the mean intensities of symmetry-equivalent reflections.</p>b<p><i>R</i><sub>work</sub> = Σ<sub>h</sub>|<i>F</i><sub>o</sub>−<i>F</i><sub>c</sub>|/Σ<sub>h</sub><i>F</i><sub>o</sub>, where <i>F</i><sub>o</sub> and <i>F</i><sub>c</sub> are the observed and calculated structure factor amplitudes, respectively.</p>c<p><i>R</i><sub>free</sub> value was calculated for <i>R</i> factor, using only a test set of reflections (5% of the total) not used in the refinement.</p>d<p>Ramachandran plot was evaluated using Molprobity <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085875#pone.0085875-Chen1" target="_blank">[32]</a>.</p>