Figure_5.tif (913.57 kB)
Cytidine deaminase (CDA) inhibition does not participate in cell proliferation.
figure
posted on 2013-02-20, 05:14 authored by Naotake Funamizu, Curtis Ray Lacy, Kaori Fujita, Kenei Furukawa, Takeyuki Misawa, Katsuhiko Yanaga, Yoshinobu ManomeA. After transfecting siRNA against CDA, real-time PCR analysis of CDA expression in MIAPaCa-2, H441, and H1299 exhibited cell growth inhibition by THU. Statistical significance was confirmed using a t-test at Day4. B. After knocking down CDA, a proliferation assay was performed. Down-regulated CDA did not affect cell growth in MIAPaCa-2, H441, and H1229 cell lines. C. A combination therapy of CDA knockdown and THU did not show any differences compared to THU alone.
