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Curcumin and Radiation have synergistic antitumor activity against ARMS xenografts.
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posted on 2013-02-07, 00:50 authored by W. Shannon Orr, Jason W. Denbo, Karim R. Saab, Catherine Y. Ng, Jianrong Wu, Kui Li, Jo Meagan Garner, Christopher L. Morton, Ziyun Du, Lawrence M. Pfeffer, Andrew M. Davidoff(A) The combination of curcumin and radiation had synergistic antitumor activity in the Rh30 xenografts (synergistic index = −0.940, SE 0.072, 95% confidence interval −1.080, −0.799). In the Rh41 cell line, the combination of curcumin and radiation was also synergistic (synergistic index = −0.915, SE 0.141, 95% confidence interval (−1.192, −0.638). (B) The antitumor activity when curcumin was given either concomitantly with or prior to radiation.
