Crystal structure of insulin (PDB ID: 9INS) [<b>68</b>] with 90° rotation.

2011-11-21T00:21:48Z (GMT) by Mahvish Muzaffar Atta Ahmad
<p>Dark colored (blue) element corresponds to chain-A and light colored (green) to chain-B of insulin in the central structures. The three disulfide bond of insulin have been shown by solid arrows. The dotted arrows indicate the N- and C-terminal segments of chain-B. The dotted spheres on the left hand side of the figure show the central hydrophobic core of insulin. The surface potential of insulin molecule (blue - positive; red – negative) obtained after processing by PDB2PQR <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027906#pone.0027906-Dolinsky1" target="_blank">[69]</a> and APBS <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027906#pone.0027906-Baker1" target="_blank">[70]</a> has been shown on the right hand side of the figure. The proposed model of insulin fibrillation is depicted at the bottom of the figure (see text for details).</p>