Cortical atrophy limited in Cln6^nclf mice.

Cortical thickness was evaluated in age matched WT and Cln6^nclf mice. (A) In the S1BF, thinning begins to appear at 6 months. (B) Thinning in the M1 region is seen at 11 months. (C) Cortical thickness was unchanged in the LEnt (C) region of the cerebral cortex. (D–E) The S1BF (D) and M1 (E) regions were analyzed for possible laminar specific atrophy. Thinning is seen in lamina V of the M1 region at 11 months as well as an apparent thickening in lamina IV. Thinning is seen in the S1BF region in lamina VI at 6 months. [Mean +/− SEM (n = 3,*p≤0.05, **p≤0.01)].