Cortical atrophy limited in <i>Cln6<sup>nclf</sup></i> mice.

<p>Cortical thickness was evaluated in age matched WT and <i>Cln6<sup>nclf</sup></i> mice. (<b>A</b>) In the S1BF, thinning begins to appear at 6 months. (<b>B</b>) Thinning in the M1 region is seen at 11 months. (<b>C</b>) Cortical thickness was unchanged in the LEnt (<b>C</b>) region of the cerebral cortex. (D–E) The S1BF (<b>D</b>) and M1 (<b>E</b>) regions were analyzed for possible laminar specific atrophy. Thinning is seen in lamina V of the M1 region at 11 months as well as an apparent thickening in lamina IV. Thinning is seen in the S1BF region in lamina VI at 6 months. [Mean +/− SEM (<i>n</i> = 3,*<i>p</i>≤0.05, **<i>p</i>≤0.01)].</p>

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