posted on 2013-11-18, 03:39authored byMichael G. Schwendinger, Maria O'Rourke, Andreas Traweger, Helga Savidis-Dacho, Andreas Pilz, Daniel Portsmouth, Ian Livey, P. Noel Barrett, Brian A. Crowe
Serum antibody titers quantified by ELISA, CI-ELISA, SB assay and killing assay are shown for OspA-1/2-immunized mice which were either protected from or infected by (A) needle challenge with B. burgdorferi s.s. strain ZS7 or (B) tick challenge with B. afzelii. Shown are the geometric mean titers of each group as well as individual serum titers. P values represent the strength of the correlation of assay titers with protective efficacy as calculated by the Mann-Whitney U test. Two serum samples were unavailable for evaluation in the B. burgdorferi s.s CI and killing assays; one serum sample was unavailable for evaluation in the B. afzelii CI assay.