Figure_3.tif (782.43 kB)
Correlation of PK-PD indices (Cmax/MIC, AUC/MIC and T>MIC) with in vivo efficacy in mice for bicyclic 4-nitroimidazole analogs in total plasma concentration (A), free plasma concentration (B) and total lung concentration (C).
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posted on 2014-08-20, 04:21 authored by Suresh B. Lakshminarayana, Helena I. M. Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E. Barry III, Paul C. Ho, Ujjini H. ManjunathaEach data point represents Δ Mean log lung CFU reduction compared to untreated controls (mean value ± SEM from 5 animals). rs is the Spearman’s rank correlations coefficient.
