Correlation between the mean normalized fMRI signal for the time points 6 to 8 seconds derived from an anatomy-based region-of-interest and the subscale novelty-seeking (NS) of Cloninger's Temperament and Character Inventory (TCI).

a. Anatomy-based region-of-interest (ROI) encompassing the pregenual anterior cingulate cortex (PACC). b. fMRI timecourse plots derived from the pACC ROI. The image on the left shows the neuronal differentiation between win and lose in pACC, whereas the image on the left displays the differentiation between high and low personal relevance in the very same region. c. Mean normalized fMRI values for the time points 6 to 8 seconds. We observed a significant differentiation between the conditions “win” and “lose” in the pACC ROI (t(18) = 6.093; p<0.001). As expected and in accordance with our conjunction analysis we found a significant differentiation between high and low personal relevance in the very same region (t(18) = 2.158; p = 0.045). t-test for dependent variables, two-sided. Error bar: standard deviation. d. Correlation between novelty seeking and low personal relevance. We observed a significant negative correlation between the fMRI signal change during low personal relevance and the temperament dimension novelty seeking (r[Pearson] = −.549; p = 0.015).